Alessio CANTORE

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Description

Alessio Cantore is an Associate Professor at “Vita-Salute San Raffaele” University and Group Leader at the San Raffaele Telethon Institute for Gene Therapy (SR-Tiget), Milan, Italy. He has made important contributions to the field of liver-directed gene therapy by evaluating the efficacy and safety of systemic lentiviral vector administration in different experimental models and engineering vectors with enhanced biological properties, reduced immunogenicity, and high potency. He leads a young and dynamic group that focuses on the biotechnological aspects and translational applications of liver-directed gene transfer and editing. The team investigates lentiviral vector-mediated liver gene transfer and its stability following post-natal liver growth, homeostatic turnover, and tissue damage, and evaluates different gene therapy strategies in preclinical models of hemophilia and liver metabolic diseases, with the ultimate goal of devising advanced gene therapy products as novel treatments for affected patients.